Preliminary data from the company suggested that PGC-GLP-1 given at 3mg/kg/week for 8 weeks starting at four weeks of age could reduce the incidence of T1D in the NOD so the hypothesis that PGC-GLP-1 could possibly promote diabetes reversal in newly onset diabetic NOD mice when used in combination with anti-CD3 was tested. The gene discussed is GCG; the disease is diabetes mellitus.