We observed that cycloart-23-ene-3β, 25-diol concomitantly administered with sitagliptin produced additively decreased plasma glucose levels, increased glucagon like peptide-1, insulin secretion than the concomitantly administered with L-glutamine in vivo model of streptozotocin- nicotinamide induced diabetes in rats. The gene discussed is GCG; the disease is diabetes mellitus.