TNF and rheumatoid arthritis: Based on the findings reported by Gutierrez et al. (2007) that demonstrate the expression of GATA-1 in circulating inflammatory monocytes and its role in the maturation and survival of DCs [46] and given our in silico predictions that the Dectin-2rs7134303_G allele might create a binding site for this transcription factor, we might hypothesize that this SNP could regulate Dectin-2 expression and, consequently, to promote Dectin-2-induced NFkB activation and production of cytokines such as TNF and IL1RA, the key molecules in the ethiopathogenesis of RA.