The presence of the Dectin-2rs7134303G allele creates a nuclear protein-binding site for the transcription factor GATA-1 (GATA-binding factor 1) whereas the presence of the MCP-1rs1024611T allele, which confers protection against RA, disrupts a binding site for both GATA-1 and GATA-2 in the promoter region of the MCP-1 gene. The gene discussed is GATA2; the disease is rheumatoid arthritis.