Frequencies of the rs9138 A-allele in SPP1 (OR = 0.48, 95%CI = 0.25–0.92, P = 0.028) and the rs4937333 T-allele in ETS1 (OR = 2.28, 95%CI = 1.03–5.04, P = 0.042) were significantly increased in SLE patients with proteinuria as compared to those without. The gene discussed is SPP1; the disease is systemic lupus erythematosus.