A significant gender-gene interaction was observed for rs2230926, a polymorphism located in TNFAIP3. The frequency of the risk allele in TNFAIP3 (rs2230926G) was slightly but significantly higher in men than women with SLE (OR = 4.05, 95%CI = 1.46–11.23, P<0.05) (Table 4), whereas there were no differences between men (n = 91) and women (n = 99) in the controls. The gene discussed is TNFAIP3; the disease is systemic lupus erythematosus.