CRP and coronary artery disorder: From the macroscopic point of view, Xu et al. [47, 48] enrolled 254 stable CHD patients, collected the clinical information and ACEs in follow-up, and thus concluded a series of clinical manifestations for “toxin syndrome” in stable CHD patients including pain in substernal, headache, uneven or irregular pulse, frequent pharyngalgia, and increased high-sensitivity C-reactive protein (hs-CRP).