Adjusted by age, gender, history of DM and current smoking, NIHSS score on both admission and discharge, and the level of HDL, multivariate logistic regression model suggested a stronger correlation in poor outcome with combination of increased hs-CRP (>3 mg/L) and higher HCY (>15 μmol/L) (OR 4.487, 95% CI 1.994–10.098, P = 0.0003) or higher WBC (>6.91 × 109/L) (OR 3.174, 95% CI 1.713–5.884, P = 0.0002), compared to those combined with lower HCY (≤15 μmol/L) (OR 3.116, 95% CI 1.361–7.137, P = 0.0072) or lower WBC (≤6.91 × 109/L) (OR 2.381, 95% CI 1.284–4.415, P = 0.0059), respectively. This evidence concerns the gene CRP and diabetes mellitus.