However, as we did not perform experiments specifically inhibiting expression of IL-6 and sIL-6Rα in MDSCs in vivo, we cannot absolutely rule out the possibilities that IL-6 and sIL-6Rα responsible for metastasis could potentially be coming from other cell types in vivo either the tumor cells themselves or other cells within the tumor microenvironment. Here, IL6 is linked to neoplasm.