IL-6-expressing 4T1 cell-bearing mice showed dramatic recruitment of CD11b+Gr-1+ MDSCs in the spleen (a lymphoid organ), metastasizing organs (liver and lung) and primary tumor mass; the total number of MDSCs recruited was two to eight times higher in 4T1 cell-bearing mice than in EMT6 cell-bearing mice (Figure 1C and see Additional file 1, Figure S2). Here, ITGAM is linked to neoplasm.