Tumor expression of cytoplasmic p62 was associated with HER2 positivity (P < 0.001), whereas nuclear p62 was associated with lower histologic grade (P < 0.001), ER positivity (P < 0.001), PR positivity (P < 0.001) and lower Ki-67 LI (P < 0.001). This evidence concerns the gene ESR1 and neoplasm.