EIF2AK2 and infection: Together, the increased expression of PACT during HIV-1 replication in PBMCs (Figure 1), the increased PKR-PACT interaction at the peak of infection (Figure 2), PACT activity upon over-expression (Figures 3 and 4) and results with shRNAs (Figure 5) contribute to reach the same conclusion that PACT is a PKR inhibitor during HIV-1 replication.