IFNA1 and neoplasm: The mechanisms of tumor targeting by OVs, which include selectivity to cancer cells and/or associated endothelial cells with altered signaling pathways of RB/E2F/p16, p53, PKR, EGFR, Ras, Wnt, anti-apoptosis, hypoxia conditions, or defects in IFN and other cellular innate immune signaling pathways have been reviewed[1,3,18].