Injection of TLR3/9 ligands (polyI:C/CpG) into a tumor during the effector phase of lentivector (lv) immunization effectively rescued the function of lv-activated CD8+ TILs and decreased the percentage of Treg within the tumor, resulting in a marked improvement in the antitumor efficacy of the immunization[153]. The gene discussed is CD8A; the disease is neoplasm.