These results suggested that at the telomere level, the main changes accompanying the development of alcohol-associated cirrhosis and fibrosis predominantly involve the overexpression of POT1, RAP1, HMRE11A, HMRE11B, Ku70, Ku80, RAD50, TANK1, and Pinx1 telomere factors. This evidence concerns the gene XRCC5 and Cirrhosis.