In addition, tumor stage (P = 0.002), tumor depth (P = 0.007), tumor necrosis (P = 0.007), P53 expression (P = 0.033), DBC1 expression (P<0.001), and β-catenin expression (P = 0.020) were independent prognostic indicators of shorter OS by multivariate analysis. The gene discussed is CCAR2; the disease is neoplasm.