Expression of SIRT1 significantly correlated with tumor stage (P = 0.013), distant metastasis (P = 0.001), histological grade (P = 0.008), mitotic count (P = 0.002), Ki67 index (P = 0.014), cyclin D1 expression (P<0.001), β-catenin expression (P<0.001), P53 expression (P = 0.003), and DBC1 expression (P<0.001). The gene discussed is SIRT1; the disease is neoplasm.