SIRT1 and soft tissue sarcoma: Therefore, when considering the signaling relationship between SIRT1 and β-catenin in carcinoma [3] and a possible relationship in sarcoma, our results suggest that SIRT1- and β-catenin-related signaling may be involved in both carcinomas and sarcomas, and SIRT1- and β-catenin-related signaling could be therapeutic targets for the treatment of soft-tissue sarcomas.