From our 4C data, we found that the breast carcinoma amplified sequence family of genes (BCAS1, BCAS2, BCAS3 and BCAS4) interacts with IGFBP3. BCAS1 has been found amplified in primary breast tumors [51] and associated with a poor prognosis [52]. The gene discussed is BCAS3; the disease is breast neoplasm.