Interestingly, both cyclin A1 and DUX4 are classified to be epigenetically repressed in somatic cells, and DUX4-fl (a full-length open reading frame mRNA) is known to be a germline transcription factor specifically expressed in FSHD muscle cell lines and muscle tissue contributing to FSHD pathophysiology [27]. Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.