In this article we present evidence of cyclin A1 overexpression at both RNA and protein level in FSHD-1, but not in other muscular dystrophies such as caveolinopathy 3 (CAV 3), dysferlinopathy (DYSF) and four and a half LIM domains protein 1 deficiency (FHL1). Here, LMO1 is linked to neuromuscular disease caused by qualitative or quantitative defects of dysferlin.