RB1 and Familial prostate cancer: Tables S1, S2, S3, S4 show 10 consistently selected genes in each dataset. As expected these genes typically reveal a high node degree in the PPI network. Many of these hub genes are well known to play a role in the disease pathology, e.g. BRCA1 for all tumors [47]–[49] and AR for prostate cancer [50]. Other disease related and consistently selected genes include p53 (all datasets), EGFR (breast and prostate cancer [51], [52]), RB1 (breast and ovarian tumors [53]–[55]) and EP300 (prostate cancer [56]).