CYP27B1 and sarcoidosis: In the lung, increased CYP27B1 mRNA expression in alveolar macrophages of patients with sarcoidosis [22], [71], [72] contributes to increased pulmonary production of 1,25(OH)2D. However, whether pulmonary 1,25(OH)2D production plays a role in regulating normal biological functions in the lung is unknown.