FOXE3 and microphthalmia: For estimating the mutation age, genomic DNA from the 17 confirmed cases (34 alleles) with sclerocornea, aphakia, and microphthalmia were genotyped with 17 polymorphic markers located 3 Mb on either side of FOXE3. Three distinct haplotypes were identified: The most common haplotype, and thus considered the ancestral one, was observed in 30 out of 34 alleles; a second haplotype was identified in three alleles while a third haplotype was present in the remaining allele (Figure 1).