Diminishing ILK expression and the resulting functional consequences on tumorigenesis are mechanistically dictated by the following signaling pathways, inhibition of AKT survival pathway, leading to increased apoptosis of tumor cells; reduction of expression of matrix metalloproteinase-2 (MMP-2) and MMP-9, and upregulation of nm23-H1, a potent suppressor gene of metastasis, impairing angiogenesis, vascularity and metastasis [53]. This evidence concerns the gene MMP2 and neoplasm.