Further analysis of CD4/CD45RO or CD8/RO double-positive cells showed a statistically significant increase in CD148 expression in synovial fluid-derived T cells compared with peripheral blood T cells, and a significant increase in CD148 expression in peripheral blood T cells from RA patients compared to peripheral blood T cells from control patients (Figure 6C). The gene discussed is PTPRJ; the disease is rheumatoid arthritis.