Second, the blood injected to the brain parenchyma seemed comparable to the hematoma away from the epicenter in the spinal cord, but the injected blood in the brain induced TLR4-NF-κB signal activated from 1 day after hemorrhage, and peaked at 3 days [10-12,32], a profile similar to that of epicenter of SCI model. The gene discussed is TLR4; the disease is hemorrhage.