In LRRK2 gene locus, we observed that the minor allele LRRK2 rs1873613A and homozygous genotype rs1873613AA were more frequent in leprosy patients than in controls conferring an increased risk of leprosy (OR = 1.7, 95% CI = 1.25–2.2, P = 0.0003 and OR = 2.04, 95% CI = 1.2–3.6, P = 0.007, respectively). Here, LRRK2 is linked to leprosy.