We investigated the possible association of gene variants NOD2 (rs9302752A/G), LRRK2 (rs1873613A/G) and RIPK2 (rs40457A/G and rs42490G/A) that are vital for NOD2 signalling and subsequent activation of the NF-kB complex in a cohort of clinically classified leprosy patients. The gene discussed is NOD2; the disease is leprosy.