Some of these cytokines namely IL-6, IL-8 (the human equivalent of murine KC) and MCP-1 have been previously shown to be up-regulated by PAR1 activation or down-regulated by PAR1 inhibition in non-infected human respiratory epithelial cells in models of asthma and idiopathic pulmonary fibrosis [61–64]. The gene discussed is CALCA; the disease is idiopathic pulmonary fibrosis.