MYT1L and cardia cancer: As shown in Table 4, two variables (TNM stage and MYT1L rs17039396) were included in the regression model by stepwise selection of the covariant variables and rs17039396 SNP was shown to be an independent protective factor for cardia cancer with a 44% decreased risk (HR = 0.56, 95%CI = 0.39–0.79, P = 0.001).