CD4 and infection: Among the 76 participants for whom HIV-1 clinical measurements were available at 12 months post-infection, a modest yet statistically significant correlation was observed between baseline Gag-Protease replication capacity and viral load at 12 months (Spearman's r = 0.2, p = 0.05, Figure 4A), but no such association was observed with CD4+ cell counts at 12 months post-infection (Figure 4B).