HIF-1α is overexpressed in regional or distant metastases and is also expressed higher in preneoplastic and premalignant lesions, indicating that overexpression of HIF-1α can occur very early in carcinogenesis which may become a potential biomarker of predicting tumor progress [29] and a good target for the detecting of tumor metastasis. The gene discussed is HIF1A; the disease is neoplasm.