Papillary thyroid carcinomas (PTCs) are the most frequent cancers of the thyroid gland, and they are usually well differentiated given their ability to i) take up iodine, ii) secrete thyroglobulin (TG), and iii) be responsive to thyroid-stimulating hormone (TSH; Nikiforov & Nikiforova 2011). The gene discussed is TG; the disease is thyroid cancer.