However, this analysis may have been confounded by many factors: effects may be brain-region or cell-population specific, as in SCN1A-related Dravet syndrome, where consequences are only found in interneurons (Ogiwara et al., 2007); our whole-tissue expression analysis would not detect such subtle signals. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.