SCN1A and mesial temporal lobe epilepsy with hippocampal sclerosis: Eventual reliable prediction of significant risk of MTLEHS after febrile seizures could lead to novel preventative measures in at-risk individuals: here, we note that SCN1A encodes an important anti-epileptic drug target and that it is possible to pharmacologically prevent the development of epilepsy after febrile seizures in an animal model (Koyama et al., 2012).