SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Notably, our association is with a syndrome involving hippocampal damage, whereas typically no hippocampal damage is observed in patients with Dravet syndrome caused by deleterious changes affecting SCN1A (Catarino et al., 2011), suggesting that SCN1A might influence epileptogenesis through various mechanisms.