If the association does indeed relate to SCN1A and function of the encoded protein, new lines of investigation may prove possible in the context of the existing deep knowledge of SCN1A, experimental models of MTLE and in vitro study of mechanisms of hippocampal dysfunction in epilepsy, as well as intriguing reports of the role of SCN1A in many epilepsies, such as the suggestion that mutations in SCN1A in Dravet Syndrome may protect against hippocampal sclerosis (Auvin et al., 2008; Catarino et al., 2011). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.