More general immunosuppressive compounds reduce inflammation in DMD but fail to increase patient strength in the same manner as glucocorticoids (Griggs et al, 1993; Kissel et al, 1993), while specific targeting of NF-κB increases strength in animal models (Grounds & Torrisi, 2004; Peterson et al, 2011). Here, NFKB1 is linked to Duchenne muscular dystrophy.