The targeting of acetylcholinesterase by miR-132-3p may be indeed relevant for the association of the enzyme activity with amyloid load in LOAD (Alkalay et al, 2013; Berson et al, 2008), as well as with the anxiety phenotype and RNA metabolism impairment that are characteristic of the disease (Berson et al, 2012; Shaltiel et al, 2013). The gene discussed is ACHE; the disease is Anxiety.