These targets were confirmed using luciferase assays and we further demonstrated upregulation of FOXO1a protein in AD hippocampus samples, in agreement with previous works showing that the FOXO1a transcript is upregulated in function of the severity of the disease (Blalock et al, 2004; Gomez Ravetti et al, 2010; Liang et al, 2012), but see (Bronner et al, 2009). This evidence concerns the gene FOXO1 and Alzheimer disease.