RAF1 and cancer: Numerous targets of PIN1 were often deregulated in cancer, such as p53 [28], [29], p73 [30], beta-catenin [12], [31], cyclin D [13], [32], [33], [34], cyclin E [35], RAF1 [36], erbB2 [37] , MYC [38], and interleukin-8 [39].