However, for hospital-based studies, significant association between −842G/C polymorphisms in the PIN1 promoter region and reduced risks of cancers was found only in heterozygote comparison (CG vs GG: OR = 0.651, 95% CI: 0.572, 0.742; Pheterogeneity = 0.214), dominant model (CC/CG vs GG: OR = 0.671, 95% CI: 0.592, 0.762; Pheterogeneity = 0.194). This evidence concerns the gene PIN1 and cancer.