Five patients were selected for an initial discovery cohort based on their unambiguously decreasing BCR/ABL mRNA transcript levels (Figure 3a) following initial K562/GVAX vaccination.38 Four of these five clinically responding patients were found to have induction of new leukemia-associated IgG responses following primary vaccination (Figure 3b), and two of these four were also shown to have augmentation of pre-vaccination leukemia antigen IgG antibody levels (Figure 3c). The gene discussed is BCR; the disease is leukemia.