Pichiorri et al. reported that p53 activates the expression of miR-192, miR-194 and miR-215 and these miRNAs target the Mdm2 3′-UTR to repress its expression; thus, downregulation of p53-inducible miR-192, miR-194 and miR-215 causes aberrant Mdm2 increase and p53 downregulation in multiple myeloma [89]. Here, TP53 is linked to plasma cell myeloma.