The Cardiovascular Risk Evaluation in patients with type 2 Diabetes on Insulin Therapy (CREDIT) study is an international, multicenter (314 centers), non-interventional investigation of the effects of long-term (4 years) glycemic control following initiation of insulin treatment on the risk reduction of cardiovascular (CV) events associated with T2DM in a large cohort of patients (n = 3,031) [11]. The gene discussed is INS; the disease is type 2 diabetes mellitus.