In contrast, TGFβ-treated and SSc monocytes differ greatly in that Cav-A inhibits CXCR4 expression and migration in TGFβ-treated monocytes while having no effect on these parameters in SSc monocytes; 4) In cells that do not migrate well (Normal monocytes), Cav-A promotes migration due to its positive effects on both CXCR4 and F-actin levels. This evidence concerns the gene CXCR4 and systemic sclerosis.