Native GLP-1 has been shown to reduce hyperglycaemia in T2D; however, as GLP-1 is rapidly (within 2–3 minutes) degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), continuous GLP-1 infusion would be required to maintain optimal glycaemic control [32]. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.