In the present study, we investigated traditional CV risk factors (lipid profile, abnormalities in serum glucose and insulin levels, oxidative stress, BP, physical activity, and smoking), a newly recognized CV risk marker (CRP), and a series of surrogate factors (sleep quality and duration, depression, and bioelectrical PA) in obese and normal weight migraineurs and age- and BMI-matched controls, hypothesising that migraine would be associated with worse CV risk, regardless of nutritional status. The gene discussed is CRP; the disease is depressive disorder.