INS and Hypoglycemia: For patients who have not achieved fasting BG target and are not able to increase the dose of premixed insulin before dinner due to hypoglycemia after dinner, it is suggested that they replace the dinner dose of LM50 with a premixed insulin containing a less rapid-acting component, and maintain the same concentration of rapid and basal insulin before breakfast and lunch if the goals for those time points have been achieved [18,20].