All antigens, and particularly EZR, VCL, VIM, PDC6I, hnRNPL and ANXA2 induced a specific antibody response in KC and KPC already at 1 to 3 months of age (Figure 2A-B), when the tumor stage was limited to early PanIN (Additional file 1: Figure S1B and E). The gene discussed is VIM; the disease is keratoconus.