Inflammation in COPD is complicated, with inflammatory and structural cells that release various mediators, including mediators such as LTB4, IL-8 and GCP-2, which were chemoattractant for neutrophil and chemokines such as MCP-1 and MIP-1α, which attract macrophage [31]. The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.