Lmo7 regulates breast cancer cell migration by acting synergistically with the small GTPase RhoA to reduce G:F-actin ratios, leading to the activation of myocardin-related transcription factor (MRTF; also known as MAL or MKL1), a serum response factor (SRF) cofactor that activates cytoskeletal genes (Hu et al., 2011; Ho et al., 2013). Here, SRF is linked to breast carcinoma.