Based on recent findings, stressful conditions of the tumour milieu may modulate some of the transfer mechanisms, for example, vascular endothelial growth factor (VEGF), interleukin 1β and FasL were shown to reside inside vesicles, and to evoke tumour-promoting activities only when liberated upon disruption of vesicle membrane integrity (52, 75, 76). This evidence concerns the gene FASLG and neoplasm.