As shown in Figure 3C, inhibition of mTOR with rapamycin significantly decreased the sensitivity of ALL cells to metformin and, these effects correlated with decreased phosphorylation (activation) of the negative regulator of protein synthesis 4EBP1 (T70), suggesting a decrease in protein synthesis (Figure 3C). The gene discussed is EIF4EBP1; the disease is acute lymphoblastic leukemia.