NPR2 and Hyperglycemia: When the two groups, lean and obese Zucker rats, were further divided and studied during fasting conditions (COfc and Ofc) and during the induction of acute hyperglycemia (COAH and OAH), significant mRNA expression levels were obtained for BNP in the hyperglycemic group (COAH vs OAH, p = 0.03) and for NPR-B in fasting rats (COfc vs Ofc, p = 0.02) (Fig. 3).