H. pylori CagL-Y58/E59, the gastric cancer strain inducing gastric epithelial cells to have greater CagA translocation, IL-8 secretion, as well as to have higher integrin β1, FAK, EGFR and AKT activation than H. pylori CagL-Y58D/E59K did. The gene discussed is AKT1; the disease is gastric cancer.