CLL patients exhibited significantly elevated Pgrn levels (median: 165.5 ng/ml, range: 20.8–1021.6 ng/ml) as compared to normal controls (median: 38.4 ng/ml, range: 20.0–93.0 ng/ml; Figure 1) with no apparent differences for age and sex (p>0.05, data not shown). Here, GRN is linked to B-cell chronic lymphocytic leukemia.