Additionally, mEpCAM and hEpCAM are newly identified substrates for the aspartyl protease BACE1, also termed β-secretase, which is central to the generation of the pathologic Aβ fragment of the amyloid precursor protein APP in Alzheimer’s disease [44], [45], [46], and might therefore also be involved in the production of mEp-β, itself a newly defined fragment of EpCAM (Figure 8). This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.