INS and type 2 diabetes mellitus: Figure 3 summarizes this point very well: despite an apparently very good data fit, ISCOMO was estimated at 10−10 for an IFG subject and ISDMMO was estimated at 3.26×10−3 (a very large value) for a T2DM subject; for these two subjects, SIMO (Figure 5 panels A2–A3 and B2–B3) estimated insulin sensitivity at respectively 3.24×10−5 and 4.58×10−5, well within physiologically plausible limits.