Acute promyelocytic leukaemia (APML) constitutes 5–10% of acute myeloid leukaemia (AML) and is characterised by a reciprocal translocation between chromosomes 15 and 17 [1], leading to the fusion of retinoic acid receptor alpha (RARA) gene on chromosome 17 at q21 and promyelocytic leukaemia (PML) gene on chromosome 15 at q22. The gene discussed is PML; the disease is acute promyelocytic leukemia.