EGFR and glioblastoma: ECOP (EGFR-coamplified and overexpressed protein), a gene which is amplified and overexpressed in at least a third of glioblastomas with EGFR amplification (Eley et al., 2002), is known to be a key regulator of NF-κB transcriptional activity that can contribute to cell survival (Park and James, 2005).