While the contribution of CD38 to the increase in ADPR after stimulation is still unclear, the basal ADPR seems to be independent of CD38 as the murine T-lymphoma line BW5147 that lacks transcripts for CD38 (77) has even higher basal ADPR levels [73 μmol/L (72)] than Jurkat cells. The gene discussed is CD38; the disease is lymphoma.